The office of Regional Outreach and Innovation (ROI) was established to support the online degree and partnership programs of Eastern Oregon University (EOU). ROI has regional centers across the state of Oregon, with admissions, academic advising and support services available at each center. A number of the centers are hosted by valued community college partners, with transfer agreements and shared services, and in some cases co-admission and co-enrollment.

ROI has a dual-focus: to assist prospective students interested in EOU; and to work with current EOU students completing their degrees. ROI adapts and connects the needs of business, industry and educational partners to enable academic programming in specific areas that link EOU students to the real world.